Bioinformatics in Epigenetics

Introduction of Epigenetics

Epigenetics is a reversible way of regulating gene expression. Through chemical modification of DNA and histones, it is determined whether specific genes can be expressed. Epigenetics regulates the occurrence and development of a variety of life activities and diseases, and has become a research hotspot in the field of life sciences in recent years, prompting breakthroughs in research in multiple fields of biology. With the advancement of experiments and sequencing technologies, massive amounts of epigenome data are currently being produced. Mining biological characteristics from these data is of great significance to understanding the physiological and pathological processes of life. Faced with massive amounts of data including DNA methylation profiles, histone modification profiles, and chromosome open information, researchers have developed analysis tools and strategies for different data. Understanding and mastering the analysis methods of epigenome data will help researchers engaged in epigenome research to dig deeper into the regulation mechanisms of important processes such as disease, development and aging, and provide potential targets for further experimental and clinical application research. CD Genomics relies on years of data analysis experience to provide scientific research assistance to researchers.

Fig 1. Alcohol-mediated epigenetic targets of neural development. (Resendiz M,et al. 2014)

Significance of Epigenetics Data Analysis

• DNA methylation analysis: quantitatively study the methylation patterns of the genome using technologies based on sequencing and microarrays.
• DNA-protein interaction analysis: In-depth understanding of the interaction between protein and DNA, to study the potential effects of chromatin modification and local structural changes on gene expression. 
• Chromatin accessibility analysis: Use ATAC-Seq to evaluate open chromatin regions in the genome. ATAC-Seq can perform high-resolution sequencing on a large number of cell populations or single cells.

Epigenetics Data Analysis Process

Fig 2. Whole-genome bisulfite methylation sequencing data analysis pipeline.

Application of Epigenetics Data in Biomedical Research

• Complex disease research: By analyzing the epigenetics data of normal samples and diseased samples, mining-related mutation information, finding genetic mutations related to the occurrence and development of complex diseases, and discovering disease mechanisms.
• Personalized diagnosis and treatment: By understanding the occurrence and development of related diseases from the genetic level, it will bring new technologies and new methods for the diagnosis and treatment of diseases, such as genetic diagnosis, gene therapy, and targeted drugs.

What We Offer

As one of the providers of epigenetics data analysis, CD Genomics offers established, cost-efficient and rapid turnaround analysis services for data analysis. The raw input sequencing data can be produced from a range of platforms. In addition, we are able to receive various formats of data for analysis such as raw FastQ/Fasta files, or aligned BAM/SAM files and other intermediate data formats. For data analysis, we will provide you with the following services:

• Researchers only need to provide raw data and inform us of your analysis needs, and we will provide you with a one-stop data analysis service.
• We will select the appropriate analysis software or model based on the data and generate high-quality results charts. 
• It is also worth mentioning that we provide customers with personalized analysis services.

Our Service Process

Epigenetics is the study of hereditary changes in gene activity caused by mechanisms other than DNA sequence changes. CD Genomics provides a series of epigenetic data analysis services based on next-generation sequencing (NGS) and microarray data, which can provide reliable, easy-to-use and cost-effective solutions for studying epigenetic modifications and their effects on gene regulation. The epigenetic analysis research provided by CD Genomics involves changes in DNA methylation, DNA-protein interaction, chromatin accessibility, histone modification, etc., to ensure that its solutions can meet the rapidly changing needs of this field. If you have any questions about the data analysis content, turnaround time and price, please feel free to contact us. We look forward to working with you, and we will provide you with satisfactory services.

Reference

1. Resendiz M,et al. Epigenetic regulation of the neural transcriptome and alcohol interference during development[J]. Frontiers in Genetics, 2014, 5:285.

* For research use only. Not for use in clinical diagnosis or treatment of humans or animals.