CircRNA and Target Gene Interaction Network
Circular RNA (circRNA) is an RNA molecule with a stable circular structure that exists in eukaryotic cells. It mainly adsorbs miRNAs by acting as a molecular sponge of miRNAs. Some circRNAs can competitively bind to miRNAs, release miRNA's inhibitory effect on target genes, up-regulate the expression of target genes, and then regulate the expression of target genes at the transcriptional level. miRNA is closely related to the occurrence of diseases, therefore, circRNA also plays an important role in the occurrence of diseases. In addition, circular RNA can strictly regulate the process of cell reproduction and growth at the pre-transcription, post-transcription and translation levels by combining different types of functional proteins. Circular RNA, as a star molecule that continues to be researched, is different from its rich expression profile research, and the research on the functional mechanism of circular RNA is only in its infancy. Therefore, the analysis of the circRNA-miRNA-mRNA regulatory network will provide new insights in the field of disease prevention, diagnosis, and treatment.
An Example of Regulatory Network
Figure1. circRNA–miRNA–mRNA regulatory network. Square, hexagon, diamond, and circle represent up-regulated circRNAs, down-regulated circRNAs, miRNAs, and mRNAs. (Zou FW, et al. 2020)
With the gradual maturity of circRNA analysis methods and technologies, circRNA and target gene interaction network analysis is wildly used in biomedical research.
- Basic research: Research on the biological function of circRNA and analysis of the interaction network with miRNA and mRNA.
- Disease research: the mechanism of disease occurrence, biomarker research, disease prevention, diagnosis and treatment research.
Data Analysis Technical Route
Fig 2. Flow chart demonstrating circRNA–miRNA–mRNA regulatory network analysis.
What We Offer
As one of the providers of circular RNA and target gene interaction network analysis, CD Genomics uses cutting-edge bioinformatics analysis technology to analyze the interaction network of circRNA and miRNA, and the interaction network of circRNA and target genes. The raw input data can be downloaded from public databases or produced from a range of sequencing platforms including 10X Genomics, DropSeq etc. In addition, we are able to receive various formats of data for analysis such as raw FastQ/Fasta files, or aligned BAM/SAM files and other intermediate data formats. CD Genomics provides researchers with one-stop, mature, cost-effective and fast turnaround circular RNA and target gene interaction network analysis services to speed up your research. It is also worth mentioning that we provide customers with personalized analysis services.
Before circular RNA and target gene interaction network analysis, the first thing is to get your data ready. The raw data or intermediate data can be obtained from the following channels:
If you don't have the data for interaction network analysis, we can provide relevant help. With many years of sequencing experience, CD Genomics provides customers with one-stop services related to circRNA, miRNA, and mRNA sample extraction and sequencing. If you have any questions about the sequencing services, data analysis content, turnaround time and price, please click online inquiry.
Biomedical-Bioinformatics, a division of
- Zou FW, et al. Identification of CircRNA–miRNA–mRNA Regulatory Network in Gastrointestinal Stromal Tumor[J]. Front. Genet., 28 May 2020.
- Shi J, et al. The integrative regulatory network of circRNA and microRNA in keloid scarring[J]. Mol Biol Rep. 2020 Jan;47(1):201-209.
* For research use only. Not for use in clinical diagnosis or treatment of humans or animals.
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